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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

Low intramyocellular lipid concentrations are associated with high insulin sensitivity.

This study was carried out to determine the relationship between insulin resistance and intramuscular lipid concentration. Using a proton nuclear magnetic resonance (1H NMR) spectroscopy technique and 2-h hyperinsulinaemia-euglycaemic clamp test, researchers measured the intramyocellular lipid content (IMLC) and insulin sensitivity respectively in 23 non-obese, non-diabetic subjects. The rate of whole-body glucose uptake was also assessed in all the subjects.

Researchers discovered that high concentrations of intramuscular lipid and fasting plasma non-esterified fatty acid were associated with reduced whole-body glucose uptake. According to this study, body mass index (BMI), age, fasting insulin, glucose, triglycerides, and non-esterified fatty acids had no effect on intramyocellular lipid levels. The findings of this study show that intramuscular lipid concentration is an excellent biomarker for whole body insulin sensitivity in normal weight, non-diabetic individuals.

Research Summary Information

  • 1999
  • Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI
  • Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
  • Yes, Free full text of study was found:
  • Yes. Source of funding disclosure found
  • The Joseph-Skoda-Award 1996 of the Austrian Society for Internal Medicine and by a grant from the Austrian National Bank Grant (ÖNB Nr. 6438) both awarded to Dr. M. Roden. This study was supported by grants from the United States Public Health Service: RO1 DK 49230, 5 P60 AG 10469, P30 DK 45 735 and MO1 RR 00 125. Dr. K. Falk Petersen was supported by a Clinical Associate
  • No. Potential conflicts disclosure not found
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