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Low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observational studies.

Diets low on carbohydrates may increase total mortality risk.

This research work investigated the relationship between the consumption of low-carbohydrate diets and total mortality risk. Researchers analyzed data obtained from 17 studies that examined more than 500,000 subjects. The cardiovascular and total mortality hazard risks were assessed in all the subjects.

Researchers discovered that subjects who regularly consumed low-carbohydrate diets had high all-cause mortality risks. High intake of diets low on carbohydrates was found to have no significant effect on cardiovascular morbidity and mortality risk in this study. The findings of this analysis show that elevated total mortality risk are associated with frequent consumers of low-carbohydrate diets.

Research Summary Information

  • 2013
  • Noto H, Goto A, Tsujimoto T, Noda M.
  • Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan. noto-tky@umin.net
  • Yes, Free full text of study was found:
  • Yes. Source of funding disclosure found
  • This study was supported by a Health Sciences Research Grant (Comprehensive Research on Diabetes/Cardiovascular and Life-Style Related Diseases H22-019) from the Ministry of Health, Labour and Welfare of Japan.
  • No. Potential conflicts disclosure not found
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